A study in mice showed that partial resection (50 to 75%) of liver tumors by ultrasound was sufficient for complete recurrence of the cancer. The waves partially destroy the tumor and activate the immune system, which takes care of eliminating the rest. Breakthrough brings hope.
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[EN VIDÉO] Very high dose rate of radiotherapy for cancer The Institut Paoli-Calmettes in Marseille, an anti-cancer center, is equipped with a new radiotherapy device, Versa HD, using very high dose rates that will make it possible to improve the effectiveness of the treatment.
at OncologyThe treatment of reference is always removal of the tumor by surgery. Unfortunately, this is not possible in many situations: the tumor is so large or localized that its removal will greatly damage the surrounding tissue. In these cases, other treatments are offered – Chemotherapy Or radiation therapy – either to try to reduce the size of the tumor for subsequent surgery or to destroy it. But these treatments are not without Side effects Its effectiveness is less than surgery.
A promising new method for the mechanical destruction of cancers, called tissue fragmentation, was published March 22, 2022 in the journal. cancer. It is a treatment by Ultrasound Which makes it possible to eliminate the tumor with millimeter precision, without surgery, in a non-surgical way.
Tissue fragmentation, a promising treatment using ultrasound
This is a technique that uses ultrasound, such as Ultrasound. But these are not quite the same waves: tissue fragmentation waves have a much greater amplitude. These lead to violent mechanical stresses that break the structure of the cancer cells. Millimeter targeting limits effects on healthy cells.
Enough partial destruction
The authors wish to evaluate the effects of partial destruction of tumoron the order of 50 to 75%, by lithotripsy in rats Liver Cancer. The end points were tumor progression, overall survival, and incidence of metastases. The results show that the fileeradication Partial tumors resulted in total tumor regression in 81% of cases without relapse or metastasis. Ultrasound destroys part of the cancer cells and activates the immune system responsible for termination of function, preventing relapses and the spread of cancer cells that can lead to the birth of metastases. In comparison, 100% of untreated mice experienced both tumor progression and malignant spread. Furthermore, the survival of the treated mice was significantly better than that of the untreated mice.
This technology is very promising. On the one hand, it is non-surgical, which limits the risks associated with surgery andAnesthesia. On the other hand, a partial resection is sufficient: this is a significant advance for hard-to-reach tumors. If it is only being tested on liver cancers at the moment, it may also be useful for other sites.
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